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Fatigue often described as one of the most debilitating factors that decrease the quality of life. It is usually described as an endless feeling of being weak, tired, worn out, slow or heavy. It is a very common symptom for who are affected by all types and grades of a brain tumor. This condition is characterized by overwhelming tiredness that cannot be remedied by a good night’s sleep. Many people say that it is one of the most disturbing side-effects they experience and also they unable to participate in normal daily activities. Cancer-related fatigue is often talked about, but less acknowledged is that people with low-grade brain tumors also often experience fatigue. Fatigue can be the first sign of something wrong that sends patients to their doctors, leading to brain tumor diagnosis. Fatigue may also brunt people during brain tumor treatment such as radiotherapy, chemotherapy, and surgery. Brain tumor and cancer, in general, can cause fatigue as well as emotional stress. I